エピゲノム研究　環境により遺伝子に刷り込まれた“刻印”の解明をめざす

群馬大学生体調節研究所 附属生体情報ゲノムリソースセンター

ゲノム科学リソース分野 HATADA Laboratory

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業績

2024年

原著論文

• Kobayashi R, Tajika Y, Kohmaru J, Morita S, Horii T, Mizukami Y, Aikawa S, Hirota Y, Hatada I. 
  The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells. 
  Cell Death Discov. 2024 Aug 8;10(1):357. doi: 10.1038/s41420-024-02134-9. 
• Maruyama T, Matsui S, Kobayashi R, Horii T, Oguri Y, Tsuzuki S, Horie T, Ono K, Hatada I, Sasaki. 
  M. 
  Am J Physiol Endocrinol Metab. 2024 Apr 10. doi: 10.1152/ajpendo.00031.2024. 
• Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I et al. 
  Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. 
  Elife. 2024 Mar 26:12:RP89376. doi: 10.7554/eLife.89376.
• Chaomulige, Matsuo T, Sugimoto K, Miyaji M, Hosoya O, Ueda M, Kobayashi R, Horii T, Hatada I.
  Morphometric Analysis of the Eye by Magnetic Resonance Imaging in MGST2- Gene-Deficient Mice.
  Biomedicines  2024 Feb 5;12(2):370. doi: 10.3390/biomedicines12020370.
• Kawabata H, Konno A, Matsuzaki Y, Sato Y, Kawachi M, Aoki R, Tsutsumi S, Togai S, Kobayashi R, Horii T, Hatada I, Hirai H.
  Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization.
  Mol Ther Methods Clin Dev.  2024 Jan 10;32(1):101185. doi: 10.1016/j.omtm.2024.101185. eCollection 2024 Mar 14.

総説・著書

• Morita S, Horii T, Hatada I
  Optimized Protocol for the Regulation of DNA Methylation and Gene Expression Using Modified dCas9-SunTag Platforms.
  Methods Mol Biol.　2024:2842:155-165. doi: 10.1007/978-1-0716-4051-7_7.

2023年

原著論文

• Morita S, Horii T, Kimura M, Kobayashi R, Tanaka H, Akita H, Hatada I.
  A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice.
  Int J Mol Sci.   2023 Sep 19;24(18):14299. doi: 10.3390/ijms241814299.
  
• Kobayashi R, Kawabata-Iwakawa R, Terakawa J, Sugiyama M, Morita S, Horii T, Hatada I.
  Aberrant activation of estrogen receptor-α signaling in Mettl14-deficient uteri impairs embryo implantation.
  FASEB J.  2023 Aug;37(8):e23093. doi: 10.1096/fj.202300735R.
• Suzuki T, Komatsu T, Shibata H, Tanioka A, Vargas D, Kawabata-Iwakawa R, Miura F, Masuda S, Hayashi M, Tanimura-Inagaki K, Morita S, Kohmaru J, Adachi K, Tobo M, Obinata H, Hirayama T, Kimura H, Sakai J, Nagasawa H, Itabashi H, Hatada I, Ito T, Inagaki T.
  Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity.
  Nucleic Acids Res.  2023 May 9;gkad342. doi: 10.1093/nar/gkad342. Online ahead of print.
• Taniuchi Y, Hiraide K, Su R, Ijuin K, Wei X, Horii T, Hatada I, Lee J.
  Analysis of absolute amounts of two meiotic cohesin subunits, RAD21L and REC8, in mouse spermatocytes.
  J Reprod Dev.  2023 Feb 3. doi: 10.1262/jrd.2022-075. Online ahead of print.

総説・著書

• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集マウス
  遺伝子治療開発研究ハンドブック　（日本遺伝子細胞治療学会編集）エヌ・ティー・エス, 第２章第４節　p.111-116, 2023
• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集とその応用について
  ゲノム編集技術 情報機構, 33-41, 2023
• Kobayashi R, Horii T, Hatada I.
  Efficient Detection of Flox Mice Using In Vitro Cre Recombination.
  Methods Mol Biol.  2023;2637:149-159. doi: 10.1007/978-1-0716-3016-7_12.
• Horii T, Kobayashi R, Hatada I.
  Generation of Floxed Mice by Sequential Electroporation.
  Methods Mol Biol.  2023;2637:135-147. doi: 10.1007/978-1-0716-3016-7_11.
• Horii T, Hatada I.
  Generation of Genome-Edited Mice by Cytoplasmic Injection of CRISPR-Cas9 RNA.
  Methods Mol Biol.  2023;2637:75-86. doi: 10.1007/978-1-0716-3016-7_6.
• Hatada I, Morita S, Horii T.
  CRISPR/Cas9.
  Methods Mol Biol.  2023;2637:41-47. doi: 10.1007/978-1-0716-3016-7_3.

2022年

原著論文

• Horii T, Morita S, Kimura M, Hatada I.
  Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system.
  Epigenetics Chromatin  
  2022 Dec 16;15(1):40.
   doi: 10.1186/s13072-022-00474-3.
• Kobayashi R, Kawabata-Iwakawa R, Sugiyama M, Oyama T, Ohtsuka M, Horii T, Morita S, Nishiyama M, Hatada I.
  Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice.
  Int J Cancer.  2022 Nov 15. doi: 10.1002/ijc.34342. Online ahead of print. 
• Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O.
  The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
  Nat Commun.  2022 Oct 28;13(1):6435. doi: 10.1038/s41467-022-34078-y.
• Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H.
  Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination.
  Proc Natl Acad Sci U S A  2022 Feb 15;119(7):e2113336119. doi: 10.1073/pnas.2113336119.
• Uchiyama S, Yoshihara K, Kawanabe R, Hatada I, Koga K, Tsuda M.
  Stress-induced antinociception to noxious heat requires α 1A-adrenaline receptors of spinal inhibitory neurons in mice.
  Molecular Brain  2022 Jan 3;15(1):6. doi: 10.1186/s13041-021-00895-3.

総説・著書

• Horii T, Morita S, Hatada I.
  Generation of Epigenetic Disease Model Mice by Targeted Demethylation of the Epigenome
  Methods Mol Biol., 2023; 2577: 255-268. doi: 10.1007/978-1-0716-2724-2_18.
• Morita S, Horii T, Hatada I.
  Regulation of Gene Expression Using dCas9-SunTag Platforms
  Methods Mol Biol., 2023; 2577: 189-195. doi: 10.1007/978-1-0716-2724-2_13.
• 森田純代、堀居拓郎、畑田出穂
  環境の影響が次世代に伝播するメカニズム－父親の食事が子に与える影響を中心として－
  遺伝子医学 12(4) 34-39, 2022
• 小林良祐、堀居拓郎、畑田出穂
  実験動物（マウス）におけるゲノム編集：疾患モデルマウス作製の実際
  JMOR 39(1) 9-15, 2022
• 河野大輔、堀居拓郎、森田純代、常岡明加、畑田出穂
  DNAメチル化修飾の栄養素・代謝物・肥満との関連と操作技術
  実験医学　増刊号 40(7) 170-176, 2022

2021年

原著論文

• Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, Yoshida K.
  Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient.
  Commun Biol.  2021 Oct 20;4(1):1204. doi: 10.1038/s42003-021-02734-6..
• Kawanabe R, Yoshihara K, Hatada I, Tsuda M.
  Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling.
  Molecular Brain  2021 May 10;14(1):79. doi: 10.1186/s13041-021-00788-5.
• Shiraishi Y, Koga K, Yamagata R, Hatada I, Shiratori-Hayashi M, Tsuda M.
  α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice.
  Molecular Brain  2021 Mar 16;14(1):55.　doi: 10.1186/s13041-021-00768-9.
• Sugimoto H, Horii T, Hirota J, Sano Y, Shinoda Y, Konno A, Hirai H, Ishizaki Y, Hirase H, Hatada I, Furuichi T & Sadakata T.
  The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice.
  Molecular Brain  2021 Mar 12;14(1):52.　doi: 10.1186/s13041-021-00766-x.

総説・著書

• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集による疾患モデル動物の作製
  細胞 53, 42-46, 2021
• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集による先天性疾患モデル動物の作製
  遺伝子医学MOOK 36, 51-57, 2021　
• 堀居拓郎、森田純代、畑田出穂
  狙ったエピゲノムが変異した疾患モデル動物の開発
  BIO Clinica 　36(5) 103-108, 2021

2020年

原著論文

• Kohro Y, Matsuda T, Yoshihara K, Kohno K, Koga K, Katsuragi R, Oka T, Tashima R, Muneta S, Yamane T, Okada S, Momokino K, Furusho A, Hamase K, Oti T, Sakamoto H, Hayashida K, Kobayashi R, Horii T, Hatada I, Tozaki-Saitoh H, Mikoshiba K, Taylor V, Inoue K, Tsuda M.
  Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
  Nat Neurosci.  2020 Nov;23(11):1376-1387. doi: 10.1038/s41593-020-00713-4. Epub 2020 Oct 5. PMID: 33020652.
• Horii T, Kobayashi R, Kimura M, Morita S, Hatada I. Calcium-Free and Cytochalasin B Treatment Inhibits Blastomere Fusion in 2-Cell Stage Embryos for the Generation of Floxed Mice via Sequential Electroporation.
  Cells 2020 Apr 28;9(5). pii: E1088. doi: 10.3390/cells9051088.
• Horii T, Morita S, Hino S, Kimura M, Hino Y, Kogo H, Nakao M & Hatada I. Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome.
  Genome Biology 2020 Apr 1;21(1):77. doi: 10.1186/s13059-020-01991-8. PubMed PMID:32198422; PubMed Central PMCID: PMC7083849.
• Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y. Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing.
  Sci Rep. 2020 Mar 20;10(1):5181. doi: 10.1038/s41598-020-62035-6. PubMed PMID:32198422; PubMed Central PMCID: PMC7083849.
• Sato M, Miyagasako R, Takabayashi S, Ohtsuka M, Hatada I, Horii T. Sequential i-GONAD: An Improved In Vivo Technique for CRISPR/Cas9-Based Genetic Manipulations in Mice.
  Cells 2020 Feb 26;9(3). pii: E546. doi:10.3390/cells9030546. PubMed PMID: 32110989.
• Morita S, Horii T, Kimura M, Hatada I. Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform.
  Int J Mol Sci. 2020 Feb 25;21(5). pii: E1574. doi: 10.3390/ijms21051574. PubMed PMID: 32106616; PubMed Central PMCID: PMC7084704.
• Wright CB, Uehara H, Kim Y, Yasuma T, Yasuma R, Hirahara S, Makin RD, Apicella I, Pereira F, Nagasaka Y, Narendran S, Fukuda S, Albuquerque R, Fowler BJ, Bastos-Carvalho A, Georgel P, Hatada I, Chang B, Kerur N, Ambati BK, Ambati J, Gelfand BD. Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.
  Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2579-2587. doi:10.1073/pnas.1909761117. 
• Watanabe H, Higashimoto K, Miyake N, Morita S, Horii T, Kimura M, Suzuki T,Maeda T, Hidaka H, Aoki S, Yatsuki H, Okamoto N, Uemura T, Hatada I, Matsumoto N,Soejima H. DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2-DMR0 as a DNA methylation-dependent, P0 promoter-specific enhancer.
  FASEB J. 2020 Jan;34(1):960-973. doi: 10.1096/fj.201901757R. Epub 2019 Nov 28.PubMed PMID: 31914674.

総説・著書

• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集による細胞運命制御
  ダイレクトリプログラミング ~再生医療の新展開 　鈴木淳史編 NTS inc, 195-201, 2020
• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集による新しい疾患モデル動物
  Precision Medicine Vol.3, No.6 64-69, 2020
• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集技術
  医学のあゆみ Vol.273, No.9 762-766, 2020
• 堀居拓郎、森田純代、畑田出穂
  ゲノム編集とエピゲノム編集
  遺伝子医学 Vol.10, No.1 80-84, 2020
• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集疾患モデル動物作製法
  実験医学 Vol.38, No.13 2251-2260, 2020
• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集と医療応用
  遺伝子医学 Vol.10, No.4 28-33, 2020 

2019年

原著論文

• Gailhouste L, Liew LC, Yasukawa K, Hatada I, Tanaka Y, Kato T, Nakagama H,Ochiya T. MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483loss of imprinting in hepatic cancer cells.
  Cell Death Dis. 2019 Jul18;10(8):553. doi: 10.1038/s41419-019-1788-6. PubMed PMID: 31320614; PubMed Central PMCID: PMC6639415. 
• Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K,Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H. Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
  Sci Rep. 2019 May 29;9(1):8016. doi: 10.1038/s41598-019-44387-w. PubMedPMID: 31142767; PubMed Central PMCID: PMC6541644. 
• Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O. Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9.
  Nat Commun.  2019 Apr 29;10(1):1968. doi:10.1038/s41467-019-09741-6. PubMed PMID: 31036811; PubMed Central PMCID:PMC6488586.     

総説・著書

• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集：特定領域のDNA脱メチル化操作を例として
  実験医学別冊 完全版　ゲノム編集実験スタンダード CRISPR-Cas9の設計・作製と各生物種でのプロトコールを徹底解説 山本　卓，佐久間哲史／編　p119-127 , 2019
• 堀居拓郎、畑田出穂
  エピジェネティクス研究とその展望
  着床前診断検査(PGT-A)の基礎知識と細胞分離手技（末岡浩監修・荒木康久編集）医歯薬出版、p.19-28, 2019
• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集―特定のDNAメチル化領域を効率よく操作する方法の開発―
  THE LUNG perspectives Vol.27, No.1 67-71, 2019 

2018年

原著論文

• Gailhouste L, Liew LC, Yasukawa K, Hatada I, Tanaka Y, Nakagama H, Ochiya T.
  Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells.
  Mol Ther. 2018 Jul 5;26(7):1840-1854. doi: 10.1016/j.ymthe.2018.04.018. Epub 2018 Apr 26.

• Gailhouste L, Liew LC, Hatada I, Nakagama H, Ochiya T.
  Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells.
  Cell Death Dis. 2018 May 1;9(5):468. doi: 10.1038/s41419-018-0487-z.PMID: 29700299.  
• Yuan X, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y.
  Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood.
  Nat Commun. 2018 Feb 12;9(1):636. doi: 10.1038/s41467-018-03038-w. PMID: 29434210.       

総説・著書

• Morita S, Horii T, Hatada I. 
  Editing of DNA Methylation Using dCas9-Peptide Repeat and scFv-TET1 Catalytic Domain Fusions.
  Methods Mol Biol., 2018;1767:419-428. doi: 10.1007/978-1-4939-7774-1_23. PMID: 29524149.   
• 堀居拓郎、森田純代、畑田出穂
  エピゲノム編集
  日本胚移植学雑誌  40(3): 103-108, 2018
• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集による疾患治療の可能性
  血液フロンティア 28(7) 47-53, 2018 
• 森田純代、堀居拓郎、畑田出穂
  エピゲノム編集技術
  医療応用をめざすゲノム編集～最新動向から技術・論理的課題まで （化学同人）44－52, 2018

2017年

原著論文

• Gailhouste L, Liew LC, Yasukawa K, Hagiwara K, Iwazaki N, Yamada Y, Hatada I, Ochiya T.
  Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment.
  Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(3):454-457.e1. doi: 10.1016/j.jcmgh.2017.11.006. eCollection 2018 Mar.PMID: 29675460 .

• Kobayashi Y, Aizawa A, Takizawa T, Igarashi K, Hatada I, Arakawa H.
  Changes in DNA methylation in naïve T helper cells regulate the pathophysiological state in minimal-change nephrotic syndrome.
  BMC Res Notes. 2017 Sep 15;10(1):480. doi: 10.1186/s13104-017-2719-1.

• Shibutani M, Horii T, Shoji H, Morita S, Kimura M, Terawaki N, Miyakawa T, Hatada I.
  Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice.
  Int J Mol Sci. 2017  18. pii: E1872. doi: 10.3390/ijms18091872.  
• Horii T, Morita S, Kimura M, Terawaki N, Shibutani M, Hatada I.
  Efficient generation of conditional knockout mice via sequential introduction of lox sites.
  Scientific Reports 2017  Aug 11;7(1):7891. doi: 10.1038/s41598-017-08496-8.    

• Hasei J, Teramura T, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz MK, Asahara H.
  TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes.
  Scientific Reports 2017 Feb 21;7:42990. doi: 10.1038/srep42990.     

総説・著書

• Horii T, Hatada I. 
  Genome Editing Using Haploid Embryonic Stem Cells.
  Progress in Molecular Biology and Translational Science, 2017;152:84-94. 

• Horii T, Hatada I. 
  Genome Editing of Mouse by Cytoplasmic Injection.
  Methods Mol Biol., 2017;1630:55-66. doi: 10.1007/978-1-4939-7128-2_5. PubMed PMID: 28643249.
• Hatada I, Horii T.
  CRISPR/Cas9.
  Methods Mol Biol. ,2017;1630:37-42. doi: 10.1007/978-1-4939-7128-2_3. PubMed PMID: 28643247.

• 畑田出穂、森田純代、堀居拓郎
  がんmiRNAとエピジェネティクス
  miRNAの最新知識、医薬ジャーナル社刊、17-22, 2017
• 森田純代、堀居拓郎、畑田出穂
  CRISPR/Cas9ゲノム編集を応用したエピゲノム操作法の開発
  バイオサイエンスとインダストリー,75: 128-130, 2017  
• 森田純代、堀居拓郎、畑田出穂
  CRISPR/Cas9ゲノム編集を応用したエピゲノム編集法
  実験医学, 6月号 35: 1497-1502, 2017
• 森田純代、堀居拓郎、畑田出穂
  特定のゲノム領域をDNA脱メチル化する手法の開発―CRISPR/Cas9ゲノム編集を応用したエピゲノム操作法―
  化学と生物,55: 359-363, 2017  

2016年

原著論文

• Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I.
  Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions.
  Nature Biotechnology 2016 Oct;34(10):1060-1065. doi: 10.1038/nbt.3658.
• Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.
  Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. PMID: 27552911
  Nat Commun.,  2016 Aug 24;7:12547. doi: 10.1038/ncomms12547.
• Rumbajan JM, Yamaguchi Y, Nakabayashi K, Higashimoto K, Yastuki H, Nishioka K, Matsuoka K, Aoki S, Toda S, Takeda S, Seki H, Hatada I, Hata K, Soejima H, Joh K.
  The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.
  Gene, 2016 Jun 1;583(2):141-6. doi: 10.1016/j.gene.2016.02.025.

• Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O
  Structure and Engineering of Francisella novicida Cas9
  Cell, 2016 Feb 10. pii: S0092-8674(16)30053-8. doi: 10.1016/j.cell.2016.01.039. [Epub ahead of print] PubMed PMID: 26875867.
• Morita S, Nakabayashi K, Kawai T, Hayashi K, Horii T, Kimura M, Kamei Y, Ogawa Y, Hata K, Hatada I 
  Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity. 
  Scientific Reports. 2016 Feb 25;164(5):950-61. doi: 10.1016/j.cell.2016.01.039.
• Kafer GR, Li X, Horii T, Suetake I, Tajima S, Hatada I, Carlton PM. 
  5- Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability. 
  Cell Rep., 2016 Feb 16;14(6):1283-92. doi: 10.1016/j.celrep.2016.01.035.          

総説・著書

• 森田純代、畑田出穂
  肥満のエピジェネティクスとその世代間継承
  実験医学増刊,　エピゲノム研究　修飾の全体像の理解から先制・個別化医療へ, 羊土社, 34: 1617-1621, 2016 
• Horii T, Hatada I.
  Regulation of CpG methylation by Dnmt and Tet in pluripotent stem cells.
  J Reprod Dev., 2016 Aug 25;62(4):331-5. doi: 10.1262/jrd.2016-046.
• Horii T, Hatada I.
  Production of genome-edited pluripotent stem cells and mice by CRISPR/Cas.
  Endocr J. 2016;63(3):213-9. doi: 10.1507/endocrj.EJ15-0734.
• Hatada I & Horii T.
  Genome editing: A breakthrough in life science and medicine.
  Endocr J. 2016;63(2):105-10. doi: 10.1507/endocrj.EJ15-0716.
• Horii T & Hatada I.
  Challenges to increasing targeting efficiency in genome engineering.
  J Reprod Dev. 2016;62(1):7-9. doi: 10.1262/jrd.2015-151.
• 畑田出穂、堀居拓郎
  CRISPR/Casによるゲノム編集.
  内分泌・糖尿病・代謝内科, 5月号 42: 357-361, 2016 

2015年

原著論文

• Hattori M, Yokoyama Y, Hattori T, Motegi SI, Amano H, Hatada I, Ishikawa O.
  Global DNA hypomethylation and hypoxia-induced expression of the ten eleven translocation (TET) family, TET1, in scleroderma fibroblasts.
  Exp Dermatol., 2015 May 25. doi: 10.1111/exd.12767. [Epub ahead of print]     
• Horii T, Yamamoto M, Morita S, Kimura M, Nagao Y, Hatada I.
  p53 Suppresses Tetraploid Development in Mice.
  Scientific Reports, 5:8907, 2015    詳しくは
• Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.
  Ligand-Activated PPARα-Dependent DNA Demethylation Regulates the FattyAcid β-Oxidation Genes in the Postnatal Liver.
  Diabetes, 64:775-784, 2015　　　詳しくは

総説・著書

• 堀居拓郎，畑田出穂
  CRISPR/Casによる遺伝子改編マウスの作製と疾患モデル多能性幹細胞への応用.
  進化するゲノム編集技術 （真下、城石編集）エヌ・ティー・エス、第２編第５節
• Horii T & Hatada I.
  Genome Editing Using Mammalian Haploid Cells.
  Int J Mol Sci, 16:23604-23614, 2015
• 堀居拓郎，畑田出穂
  CRISPR/Casシステムによるゲノム編集の現状.
  DIABETES JOURNAL 糖尿病と代謝　6月号, 2015　
• 畑田出穂, 堀居拓郎
  ゲノム編集技術と疾患研究.
  MedicalScienceDigest ５月号, 9-12, 2015

2014年

原著論文

• Horii T, Arai Y, Yamazaki M, Morita S, Kimura M, Itoh M, Abe Y, Hatada I
  Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering.
  Scientific Reports, 4:4513, 2014　　　詳しくは、日経バイオテク
  
• Morita S, Horii T, Kimura M, Arai Y, Kamei Y, Ogawa Y, Hatada I
  Paternal Allele Influences High Fat Diet-Induced Obesity.
  PLoS One,9: e85477, 2014　　　詳しくは    BioMedサーカス、日経バイオテク

総説・著書

• Horii T, Hatada I
  Genome engineering using the CRISPR/Cas system.
  World J Med Genet, 4: 69-76, 2014　
• 畑田出穂
  疾患エピジェネティクスの現況.
  アレルギー・免疫　12月号, 1848-1854, 2014
• 畑田出穂
  医学・生物学の研究スタイルがかわる！ CRISPR/Casゲノム編集技術の革新性とその歴史的意義
  実験医学　７月号(企画 畑田出穂), 羊土社, 1690-1696, 2014　　
  
• 堀居拓郎，畑田出穂
  多能性幹細胞のCRISPR/Casがもたらす可能性
  実験医学　７月号(企画 畑田出穂), 羊土社, 1704-1708, 2014
• 堀居拓郎，荒井勇二，畑田出穂
  CRISPR/Casによるゲノム編集法の実際
  実験医学　７月号(企画 畑田出穂),  技術解説，羊土社，1737-1741, 2014
• 畑田出穂，久保田健夫
  エピジェネティクスとは
  エピジェネティクスの産業応用（畑田出穂・久保田健夫監修）シーエムシー出版，3-10，2014　
• 久保田健夫，畑田出穂
  エピジェネティクスの研究動向と政策・産業化
  エピジェネティクスの産業応用（畑田出穂・久保田健夫監修）シーエムシー出版，11-18，2014
• 堀居拓郎，畑田出穂
  マイクロアレイを用いた網羅的エピジェネティクス解析法
  エピジェネティクスの産業応用（畑田出穂・久保田健夫監修）シーエムシー出版，112-119，2014

2013年

原著論文

• Horii T, Morita S, Kimura M, Kobayashi R, Tamura D, Takahashi R, Kimura H, Suetake I, Ohata H, Okamoto K, Tajima S, Ochiya T, Abe Y, Hatada I
  Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system.
  PeerJ,1: e230, 2013　　詳しくは
• Horii T, Tamura D, Morita S, Kimura M, Hatada I
  Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System.　　　
  Int J Mol Sci,14: 19774-19781, 2013　　詳しくは　　紹介記事
• Morita S, Horii T, Kimura M, Hatada I　　
  MiR-184 regulates insulin secretion through repression of Slc25a22.
  PeerJ,1: e162, 2013　　詳しくは    紹介記事
• Morita S, Horii T, Kimura M, Ochiya T, Tajima S, Hatada I
  miR-29 represses the activities of DNA methyltransferases and DNA demethylases.
  Int J Mol Sci,14: 14647-14658, 2013  　詳しくは
• Takahashi M, Kamei Y, Ehara T, Yuan X, Suganami T, Takai-Igarashi T, Hatada I, Ogawa Y.
  Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes. 
  Biochem Biophys Res Commun.. 434:873-878, 2013  
• Gailhouste L, Gomez-Santos L, Hagiwara K, Hatada I, Kitagawa N, Kawaharada K, Thirion M, Kosaka N, Takahashi RU, Shibata T, Miyajima A, Ochiya T.
  MiR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. 
  Hepatology.. 58:1153-1165, 2013 
• Deguchi K, Nagamatsu G, Miyachi H, Kato Y, Morita S, Kimura H, Kitano S, Hatada I, Saga Y, Tachibana M, Shinkai Y.
  Posttranscriptional Regulation of Histone Lysine Methyltransferase GLP in Embryonic Male Mouse Germ Cells. 
  Biol Reprod.. 88:3, 2013 

著書

• Horii T, Hatada I.
  Epigenetic Instability in Embryonic Stem Cells. Deepa Bhartiya and Nibedita Lenka(EDS.),
  Pluripotent Stem Cells, Rijeka, Croatia:InTech, 2013:301-316.

2012年

原著論文

• Morita S, Takahashi RU, Yamashita R, Toyoda A, Horii T, Kimura M, Fujiyama A, Nakai K, Tajima S, Matoba R, Ochiya T, Hatada I*.
  Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells. 
  Int J Mol Sci. 13:8259-8272, 2012

• Kobayashi Y, Aizawa A, Takizawa T, Yoshizawa C, Horiguchi H, Ikeuchi Y, Kakegawa S, Watanabe T, Maruyama K, Morikawa A, Hatada I, Arakawa H
  DNA methylation changes between relapse and remission of minimal change nephritic syndrome.
  Pediatr Nephrol. 27:2233-2241, 2012

2011年

原著論文

• Horii T, Suetake I, Yanagisawa E, Morita S, Kimura M, Nagao Y, Imai H, Tajima S, Hatada I*.
  The Dnmt3b Splice Variant is Specifically Expressed in In　Vitro-manipulated Blastocysts and Their Derivative ES Cells.
  J Reprod Dev. 57:579-585, 2011 

• Sato N, Yamakawa N, Masuda M, Sudo K, Hatada I, Muramatsu M.
  Genome-Wide DNA Methylation Analysis Reveals Phytoestrogen Modification of Promoter Methylation Patterns during Embryonic Stem Cell Differentiation.
  PLoS One. 6:e19278, 2011 

• Obata Y, Hiura H, Fukuda A, Komiyama J, Hatada I, Kono T.
  Immature Oocytes Lead to Loss of Imprinting During Embryogenesis.
  J Reprod Dev. 57:327-334, 2011 

著書

• Horii T, Hatada I.
  Reprogrammed parthenogenetic ES cells – New choice for regenerative medicine. Atwood C(EDS.),
  Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, Rijeka, Croatia:InTech, 2011:221-236.

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2010年

原著論文

• Horii T, Yanagisawa E, Kimura M, Morita S, Hatada I*.
  Epigenetic differences between embryonic stem cells generated from blastocysts developed in vitro and in vivo.
  Cell Reprogram. 12:551-563, 2010.

*Corresponding author

著書

• Hatada I.
  The Epigenomics if Cancer. Cho WCS (EDS.),
  An Omics Perspective on Cancer Research, Dordrecht Heidelberg London New York:Springer, 2010:51-68.

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2009年

原著論文

• Horii T, Morita S, Kimura M, Hatada I*.
  Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.
  PLoS One. 4:e5809, 2009.
• Morita S, Hara A, Kojima I, Horii T, Kimura M, Kitamura T, Ochiya T, Nakanishi K, Matoba R, Matsubara K, Hatada I*.
  Dicer is required for maintaining adult pancreas.
  PLoS One. 4:e4212, 2009.

*Corresponding author

主な学会発表

• Hatada I.
  Profiling and characterization of DNA methylation targets.
  Japan-Denmark Joint Workshopon　Molecular Cancer Research, Tokyo, 2009.
• Hatada I.
  Genome-wide DNA methylation analysis of cancers.
  第6８回日本癌学会学術総会,横浜, 2009（シンポジウム）.

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2008年

原著論文

• Hatada I*, Namihira M, Morita S, Kimura M, Horii T, Nakashima K.
  Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation..
  PLoS One. 3:e3189, 2008.
• Hatada I*, Morita S, Kimura M, Horii T, Yamashita R, Nakai K.
  Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells.
  J Hum Genet. 53:185-191, 2008.
• Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T*.
  A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells.
  FEBS J.275:1260-1273, 2008.
• Nomura T, Kimura M, Horii T, Morita S, Soejima H, Kudo S, Hatada I*.
  MeCP2-dependent repression of an imprinted miR-184 released by depolarization.
  Hum Mol Genet. 17:1192-9, 2008.
• Horii T, Kimura M, Morita S, Nagao Y, Hatada I*.
  Loss of genomic imprinting in mouse parthenogenetic embryonic stem cells.
  Stem Cells. 26:79-88, 2008.

*Corresponding author

主な学会発表

• Hatada I.
  Profiling of DNA methylation targets.
  Decoding Epigenetic Code, Tokyo, 2008
• Nomura T, Kimura M., Horii T., Morita S., Soejima H., Kudo S., & Hatada I.
  MeCP2-dependent repression of an imprinted miR-184 released by depolarization.
  EMBO Workshop on Genomic Imprinting, Singapore, 2008.
• Horii T, Kimura M, Morita S, Nagao Y, & Hatada I.
  Derivation of Embryonic Stem Cells from Mouse Tetraploid Embryos and Their Character.
  The 41st Society for the study of reproduction, USA, 2008.

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2007年

原著論文

• Obata Y, Maeda Y, Hatada I, Kono T*.
  Long-term effects of in vitro growth of mouse oocytes on their maturation and development.
  J Reprod Dev. 53:1183-1190, 2007.
• Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I*.
  One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation.
  Genomics. 89:687-696, 2007.

*Corresponding author

総説

• 畑田出穂.
  ゲノムアレイを用いたDNAメチル化解析法-MIAMI,DMH,MeDIP,MeCP2,アレイに搭載するゲノム領域.
  バイオテクノロジージャーナル 7:422-427, 2007.

著書

Hatata I.

• Genome-wide DNA methylation profiling methods-from RLGS to MIAMI.
  Neumann HP (EDS.), Focus onDNA methylation Research, New York:Nova Science, 2007:173-188.

主な学会発表

• Hatada I.
  Genome-wide DNA methyaltion analysis by MIAMI.
  Epigenomics, Technology, Products, and Obstacles, Osaka, 2007.
• Hatada I.
  Microarray-Based Genome-Wide DNA Methylation Analysis.
  First JCA-AACR Special Joint Conference, Nagoya, 2007.
• Horii T, Kimura M, Morita S, Nagao Y, & Hatada I.
  Loss of imprints of parthenogenetic ES cells in murine chimeras.
  The 33st International Embryo Transfer Society, Kyoto,2007.
• Hatada I. Sakurada A, Sato M, Kondo T, Horii A, Yamamoto Y, Ochiya T, Yamashita R, Nakai K, Nakanishi K, Matoba R, Matsubara K.
  Genome-wide DNA methylation analysis of cancers.
  第66回日本癌学会学術総会, 横浜, 2007.
• 畑田出穂.
  MIAMI法を用いたゲノムワイドなメチル化のプロファイリングとその応用.
  日本エピジェネティクス研究会年会, 大阪, 2007.

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2006年

原著論文

• Hatada I*, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H.
  Genome-wide profiling of promoter methylation in human.
  Oncogene. 25:3059-3064, 2006.
• Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I*.
  Genomic imprinting in Dicer1-hypomorphic mice.
  Cytogenet Genome Res.;113:138-43, 2006.
• Fukasawa M, Kimura M, Morita S, Matsubara K, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Sasaki H, Hatada I*.
  Microarray analysis of promoter methylation in lung cancers.
  J Hum Genet.;51:368-374, 2006.

*Corresponding author

総説

• Hatada I.
  Emerging technologies for genome-wide DNA methylation profiling in cancer.
  Crit Rev Oncog. 12:205-223, 2006.
• 畑田出穂.
  DNAメチル化のゲノムワイドなプロファイリング技術.
  実験医学（増刊）ゲノムワイドに展開するエピジェネティクス医科学 24:1232-1239, 2006.

主な学会発表

• Horii T, Kimura M, Morita S, Nagao Y, & Hatada I.
  Loss of imprints of parthenogenetic ES cells in murine chimeras.
  International Genomic Imprinting Workshop, Tokyo,2006.
• Morita S, Fukasawa M, Horii T, Kimura M, Goto Y, Ochiya T & Hatada I.
  Genomic imprinting in Dicer1-hypomorphic mice and eIF2C2-deficient mice.
  International Genomic Imprinting Workshop, Tokyo,2006.

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2005年

総説

• 畑田出穂.
  ゲノム的エピジェネティクス解析方法.
  ゲノム医学 5: 481-487, 2005.

主な学会発表

• Hatada I.
  Microarray-based detection of DNA methylation.
  International Symposium on　Genome-Wide Epigenetics, Tokyo, 2005.
• 畑田出穂, 深澤正幸,木村美香,森田純代,山田和男,吉川武男,山中澄隆,桜田晃,佐藤雅美,遠藤知顕,近藤丘,堀井明,牛島俊和,佐々木裕之.
  ゲノムワイドなプロモーター領域のメチル化のプロファイリング.
  第２８回分子生物学会, 福岡, 2005.
• 畑田出穂.
  メチル化検出用マイクロアレイとその応用.
  大阪大学蛋白質研究所セミナー「染色体DNAのメチル化修飾の形成、維持と異常」, 大阪, 2005.

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2003年

主な学会発表

• Hatada I.
  In vitro culture system for studying genomic imprinting.
  6th European Meiosis Meeting. Obertraun, Austria, 2003.

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2002年

原著論文

• Hatada I*, Kato A, Morita S, Obata Y, Nagaoka K, Sakurada A, Sato M, Horii A, Tsujimoto A, Matsubara K.
  A microarray-based method for detecting methylated loci.
  J Hum Genet. 47:448-451, 2002.
• Higashimoto K, Soejima H, Yatsuki H, Joh K, Uchiyama M, Obata Y, Ono R, Wang Y, Xin Z, Zhu X, Masuko S, Ishino F, Hatada I, Jinno Y, Iwasaka T, Katsuki T, Mukai T*.
  Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse.
  Genomics. 80:575-584, 2002.
• Yatsuki H, Joh K, Higashimoto K, Soejima H, Arai Y, Wang Y, Hatada I, Obata Y, Morisaki H, Zhang Z, Nakagawachi T, Satoh Y, Mukai T*.
  Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.
  Genome Res. 12:1860-1870, 2002.
• Obata Y, Kono T, Hatada I*.
  Gene silencing: maturation of mouse fetal germ cells in vitro.
  Nature. 418:497, 2002. 　　＃同誌Vol424 News Feature他多数誌に紹介記事
• Shimoda M, Morita S, Obata Y, Sotomaru Y, Kono T, Hatada I*.
  Imprinting of a small nucleolar RNA gene on mouse chromosome 12.
  Genomics. 79:483-486, 2002.
• Sotomaru Y, Katsuzawa Y, Hatada I, Obata Y, Sasaki H, Kono T*.
  Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses.
  J Biol Chem. 277:12474-12478, 2002.

*Corresponding author

著書

• Hatada, I., & Mukai, T.,
  Mehtylation-Sensitive genome scanning. Ward, A. (EDS.),
  Mehods in Molecular Biology vol.181 Genomic Imprinting Methods and Protocols, Totowa, New Jersey:Humana Press, 2002:83-100.

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2001年

原著論文

• Hatada I*, Morita S, Obata Y, Sotomaru Y, Shimoda M, Kono T.
  Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening.
  J Biochem. 130:187-190, 2001.
• Gregory RI, Randall TE, Johnson CA, Khosla S, Hatada I, O’Neill LP, Turner BM, Feil R*.
  DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1.
  Mol Cell Biol. 21:5426-5236, 2001.
• Sotomaru Y, Kawase Y, Ueda T, Obata Y, Suzuki H, Domeki I, Hatada I, Kono T*.
  Disruption of imprinted expression of U2afbp-rs/U2af1-rs1 gene in mouse parthenogenetic fetuses.
  J Biol Chem. 276:26694-26698, 2001.

*Corresponding author

主な学会発表

• 畑田出穂
  Epigenetics研究の方法論、
  平成１３年度国立遺伝学研究所研究集会「DNAメチル化が関与する生命現象」, 三島, 2001.

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2000年

原著論文

• Schwienbacher C, Angioni A, Scelfo R, Veronese A, Calin GA, Massazza G, Hatada I, Barbanti-Brodano G, Negrini M.
  Abnormal RNA expression of 11p15 imprinted genes and kidney developmental genes in Wilms’ tumor.
  Cancer Res. 60:1521-1525, 2000.

*Corresponding author

総説

• Hatada I, Mukai T.
  Genomic imprinting and Beckwith-Wiedemann syndrome.
  Histol Histopathol. 15:309-12, 2000.
• 畑田出穂.
  ゲノム２次元電気泳動法-Restriction Landmark Genome Scanning (RLGS)法を用いたゲノムのメチル化の網羅的解析.
  Jpn. J. Electroph 44:173-175, 2000.

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1999年

原著論文

• Lam WW, Hatada I, Ohishi S, Mukai T, Joyce JA, Cole TR, Donnai D, Reik W, Schofield PN, Maher ER*.
  Analysis of germline CDKN1C (p57KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation.
  J Med Genet. 36:518-523, 1999.
• Bhuiyan ZA, Yatsuki H, Sasaguri T, Joh K, Soejima H, Zhu X, Hatada I, Morisaki H, Morisaki T, Mukai T*.
  Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome.
  Hum Genet. 104:205-210, 1999.

*Corresponding author

主な学会発表

• Hatada, I.
  Constitutive Xist expression in ES cells.
  The First International Symposium on Studying X-chromosome inactivation in mammals, Novosibirsk (Russia), 1999.
• 畑田出穂.
  癌とインプリンティング.
  大阪大学蛋白質研究所セミナー「DNAメチル化とゲノムインプリンティング」, 大阪, 1999.
• 畑田出穂.
  ゲノム２次元電気泳動法-Restriction Landmark Genome Scanning(RLGS)法を用いたゲノムのメチル化の網羅的解析.
  第５０回日本電気泳動学会総会, 宇部, 1999.

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1998年

原著論文

• Morisaki H, Hatada I, Morisaki T, Mukai T*.
  A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.
  DNA Res. 5:235-240, 1998.
• Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M*.
  Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.
  Proc Natl Acad Sci U S A. 95:3873-3878, 1998.
• Soejima H, McLay J, Hatada I, Mukai T, Jinno Y, Niikawa N, Yun K*.
  Comparative reverse transcription-polymerase chain reaction and in situ hybridization analyses of human imprinted p57KIP2 and insulin-like growth factor 2 gene transcripts in fetal kidney and Wilms’ tumors using archival tissue.
  Lab Invest. 78:19-28, 1998.

*Corresponding author

総説

• 向井常博,畑田出穂,副島英伸.
  Beckwith-Wiedemann症候群とその発症機構.
  Molecular Medicine 35:836-845, 1998.
• 畑田出穂,向井常博.
  ゲノムインプリンティングと発癌.
  Molecular Medicine 35:778-787, 1998.
• 畑田出穂, 向井常博.
  ゲノムインプリンティングと遺伝病 -メカニズムの解明に向けて.
  生化学 69:1378-1384, 1998.

主な学会発表

• Hatada, I.,
  Imprinted Genes on 11p15.5 and their Involvement in Beckwith-Wiedemann Syndrome and Cancer.
  Genomic Imprinting and Disease Susceptibility. Durham (USA), 1998.

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1997年以前

原著論文

• Hatada I*, Nabetani A, Morisaki H, Xin Z, Ohishi S, Tonoki H, Niikawa N, Inoue M, Komoto Y, Okada A, Steichen E, Ohashi H, Fukushima Y, Nakayama M, Mukai T.
  New p57KIP2 mutations in Beckwith-Wiedemann syndrome.
  Hum Genet. 100:681-683, 1997.
• Hatada I*, Nabetani A, Arai Y, Ohishi S, Suzuki M, Miyabara S, Nishimune Y, Mukai T.
  Aberrant methylation of an imprinted gene U2af1-rs1(SP2) caused by its own transgene.
  J Biol Chem. 272:9120-9122, 1997.
• Nabetani A, Hatada I, Morisaki H, Oshimura M, Mukai T*.
  Mouse U2af1-rs1 is a neomorphic imprinted gene.
  Mol Cell Biol. 17:789-798, 1997.
• Hatada I*, Ohashi H, Fukushima Y, Kaneko Y, Inoue M, Komoto Y, Okada A, Ohishi S, Nabetani A, Morisaki H, Nakayama M, Niikawa N, Mukai T.
  An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.
  Nat Genet. 14:171-173, 1996.
  ＃同号News & Viewsに紹介記事掲載
• Hatada I*, Inazawa J, Abe T, Nakayama M, Kaneko Y, Jinno Y, Niikawa N, Ohashi H, Fukushima Y, Iida K, Yutani C, Takahashi S, Chiba Y, Ohishi S, Mukai T.
  Genomic imprinting of human p57KIP2 and its reduced expression in Wilms’ tumors.
  Hum Mol Genet. 5:783-788, 1996.
• Nabetani A, Hatada I, Morisaki H, Mukai T*.
  Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11.
  Genomics. 34:246-249, 1996.
• Hatada I*, Mukai T.
  Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse.
  Nat Genet. 11:204-206, 1995.
• Hatada I*, Kitagawa K, Yamaoka T, Wang X, Arai Y, Hashido K, Ohishi S, Masuda J, Ogata J, Mukai T
  Allele-specific methylation and expression of an imprinted U2af1-rs1 (SP2) gene.
  Nucleic Acids Res. 23:36-41, 1995.
• Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, Monden M, Mukai T*
  Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.
  Genomics. 30:257-263, 1995.
• Yamaoka T, Hatada I, Kitagawa K, Wang X, Mukai T*.
  Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.
  Genomics. 27:337-340, 1995.
• Hatada I, Sugama T, Mukai T.
  A new imprinted gene cloned by a methylation-sensitive genome scanning method.
  Nucleic Acids Res. 21:5577-5582, 1993.
• Nagai H, Hirotsune S, Komatsubara H, Hatada I, Mukai T, Hayashizaki Y, Matsubara K*.
  Genomic analysis of human hepatocellular carcinomas using Restriction Landmark Genomic Scanning.
  Cancer Detect Prev. 17:399-404, 1993.
• Hayashizaki Y*, Hirotsune S, Hatada I, Tamatsukuri S, Miyamoto C, Furuichi Y, Mukai T.
  A new method for constructing NotI linking and boundary libraries using a restriction trapper.
  Genomics. 14:733-739, 1992.
• Hirotsune S, Hatada I, Komatsubara H, Nagai H, Kuma K, Kobayakawa K, Kawara T, Nakagawara A, Fujii K, Mukai T, Hayashizaki Y*.
  New approach for detection of amplification in cancer DNA using restriction landmark genomic scanning.
  Cancer Res. 52:3642-3647, 1992.
• Hatada I, Hayashizaki Y*, Hirotsune S, Komatsubara H, Mukai T.
  A genomic scanning method for higher organisms using restriction sites as landmarks.
  Proc Natl Acad Sci U S A. 88:9523-9527, 1991.
• Hatada I, Tokino T, Ochiya T, Matsubara K*.
  Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.
  Oncogene. 3:537-540, 1988.
• Shiozawa M, Ochiya T, Hatada I, Imamura T, Okudaira Y, Hiraoka H, Matsubara K*.
  The lca as an onco-fetal gene: its expression in human fetal liver.
  Oncogene. 2:523-526, 1988.
• Ochiya T, Fujiyama A, Fukushige S, Hatada I, Matsubara K*
  Molecular cloning of an oncogene from a human hepatocellular carcinoma.
  Proc Natl Acad Sci U S A. 83:4993-4997, 1986.

*Corresponding author

10.1186/s13059-020-01991-8

Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity

Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system

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